Probably not in a negative way. The pillars and everything respawn, also destroying nearby things, so each fight is pretty much a fair game. There still only is one Dragon Egg, and subsequent dragons spawned will drop considerably less exp than the original. They also open up the gateway, which can net you powerful gear and the Elytra. Despite that, it's not exactly easy to get that loot, as the new End isn't flooded with cities, and even then, each city usually only nets you around 0-2 chests, not counting the Ship which may or may not generate.
The gear isn't OP to where it has the best enchants 100% of the time (They're still great) and all enchants you can get on said armor, you can get by normal means such as enchantment books or tables, which, if you're lucky, comes sooner than exploring the End.
So essentially, yes there's powerful stuff there, but it's all fair game.