Thermal Expansion is one of the better tech mods. Its easy to setup and run.
1. First, you'll need power. Make a Dynamo.
2. Make a few energy ducts to transfer the power.
3. The first two machines to make are the Pulverizor and the Redstone Furnace. You can place one next to the other. You can configure the side outputs on the machine's interface window. This allows ore doubling.
4, You can also make an Energy Cell to store power.
5. Once you have enough mats, you can make the machine upgrades to increase the capabilities of the machines.
6. Another machine to make is the Induction Smelter. This allows you to make alloys, like bronze and invar.
As far as a room goes, that is up to you. The machines can easily be placed in a line for easy operation.