If you mean can you control the mobs from Mo Creatures and where they spawn, I assume so with the Custom Mob Spawner mod that is needed to make Mo Creatures work can. I assume? I don't have much experience with them.
That or other mods that allow for controlling spawning, locations, rate of spawning and more.
I'm not completely sure what you mean. Though I'm only guessing.
If you want those mobs in your world then sure, but if you want to say not have Lions spawn and only have certain ones that do appear on your world/map then look for some of those if you can't disable them in a config or with Custom Mob Spawner.